Genome Stability Leads to Negligible Senescence
- September 1, 2015 at 6:09 pm #28650PeterMember
What would you say if I told you that aging happens not because of accumulation of stresses, but rather because of the intrinsic properties of the gene network of the organism?
[See the full post at: Genome Stability Leads to Negligible Senescence]September 2, 2015 at 12:41 am #28652MarcosParticipant
ò.ó’September 2, 2015 at 6:30 am #28653Brad ArnoldParticipant
While Kurzweil’s nanite solution where the human body is repaired and maintained on a molecular level is the best answer, turning off the suicide genes we’ve inherited, using gene therapy, is the most promising immediate answer (as you well know Ms Konovalenko).
“Gene engineering is the most powerful existing tool for life extension. Mutations in certain genes result in up to 10-fold increase in nematode lifespan and in up to 2-fold increase in a mouse life expectancy. Gene therapy represents a unique tool to transfer achievements of gene engineering into medicine. This approach has already been proven successful for treatment of numerous diseases, in particular those of genetic and multigenic nature. More than 2000 clinical trials have been launched to date.
We propose developing a gene therapy that will radically extend lifespan. Genes that promote longevity of model animals will be used as therapeutic agents. We will manipulate not a single gene, but several aging mechanisms simultaneously. A combination of different approaches may lead to an additive or even a synergistic effect, resulting in a very long life expectancy.”
What I find most interesting is the theory that rather than the SENS paradigm that we ought to repair the cellular damage that accumulates over time, instead evolution has installed “suicide genes” that cause us to wear down, and that if those few genes are deactivated we would gain radical longevity.
“According to the study, this genetic switch is automatically flipped when a worm reaches reproductive maturity. Stress responses that originally protect its cells by keeping vital proteins folded and functional are switched off at this point, and the ageing process begins in earnest – with the switch disabled, the cells kept up their earlier level of resistance, making the worm better able to handle the wear and tear of growing older.”
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