New cow genome sequence released
Scientists from the University of Maryland have published their assembly of the domestic cow (Bos taurus), an important new resource for the genetics community. The new version of the cow genome improves considerably on other assemblies, in terms of both completeness and accuracy. The article describing their research is freely available in BioMed Central’s open access journal Genome Biology.
The research team led by Steven Salzberg developed special-purpose software to assemble 35 million DNA sequence fragments into the 30 chromosomes that make up the Bos taurus genome. The algorithms use paired-end sequence information, mapping data, and synteny with the human genome to detect errors, correct inverted segments and fill in sequence gaps. The resulting assembly has around 91% of the assembled genome anchored onto chromosomes.
The researchers believe their assembly is the best available, thanks to its completeness and the algorithm’s ability to smooth out thousands of errors. Their comparisons demonstrate that the new cow genome assembly has better agreement with independent genetic maps, and a more complete representation of cow genes, than alternative assemblies.