News from space for osteoporosis patients on earth: resistance is not futile
Bethesda, MD—Results of a space experiment published online in The FASEB Journal (http://www.fasebj.org) have yielded a giant leap for science that could translate into an important step for mankind in the ongoing battle against osteoporosis. In the report, a team of Italian scientists show for the first time that a lack of resistance (i.e., gravity) activates bone-destroying cells. This outcome helps explain more completely why bedridden patients and astronauts experience bone loss and provides an entirely new drug target for stopping the process.
"This study cuts straight to the bone in terms of why our skeletons deteriorate with disuse," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "As is the case with human intelligence, bone loss is an example of ‘use it or lose it.’ This study from space has pinpointed the cellular culprits that destroy our bones when we don’t use them to support weight."
Using two sets of bone-destroying cells, called "osteoclasts," obtained from the bone marrow of mice femurs, the scientists launched one set into space via the European Space Agency’s 2007 FOTON-M3 mission and kept the other set on Earth. On the satellite, the cells were maintained in custom-designed bioreactors equipped with automatic nutrient providers. At the same time, the other set of cells were kept in the same type of bioreactors on the Earth’s surface. After twelve days, the experiment was stopped and the cells were examined. The analysis revealed an increase in genes involved in osteoclast maturation and activity, as well as increased bone loss when compared to the cells on Earth.