CoQ10 plays a crucial role both in energy production and in detox. Our bodies make less of it as we age, and we function less well for that. For more than 30 years, supplementation with CoQ10 has been identified as a promising anti-aging strategy and preventive for diseases of the heart and the brain. But in extensive animal studies and dozens of clinical trials, CoQ10 has shown modest benefit, or none at all. Part of the problem is that, when CoQ10 is taken into the digestive system, very little of it gets to the site where it can work. Where CoQ10 belongs is in the cellular energy factories, the organelles called mitochondria. Very recently, a mitochondria-targeted form of CoQ10 has become commercially available. Preliminary experiments with MitoQ in animals and humans are very promising.