“Iron rusts from disuse; water loses its purity from stagnation and freezes by cold even so does inaction sap the vigor of the mind” (Leonardo da Vinci, 1452–1519)
Category: Health & Medicine
Recent re-analysis suggests that Alzheimer’s Disease ought to be ranked with cancer and heart disease as one of the most important mortality risks for older Americans. Some of this risk is under our control.
Carnosine is a good supplement, with many studies offering indirect evidence for effects that ought to be beneficial. Carnosine reduces glycation (“AGE’s”) that gum up the cellular works. Best of all, carnosine is a telomerase promoter. But in practice, will it help us live longer?
A lot of people still try to understand aging as a kind of accumulated damage, or wear-and-tear. Theories of oxidative damage are one poular version, and anti-oxidants have been promoted as a remedy for aging by people who should know better. One trouble with the damage theories is the of things that increase damage, but that lengthen life span. Exercise is the best example, but there are many others.
Telomere biology has the potential to extend human life span, to dramatically lower rates of the great remaining killer diseases: heart disease, stroke, and Alzheimer’s. All three diseases increase exponentially with age, and their toll will be slashed as we we learn how to address the body’s aging clocks.
Andrew Hessel, Autodesk Inc Bio/Nano Programmable Matter group; Natasha Vita-More, H+ Board Chair and transhuman pioneer; Dr. Seth ‘Adventure’, New Flesh Workshop; Lucas Dimoveo and Olivia Webb , Grindhouse Wetwares
My theme the last few weeks has been the signals that trigger the body’s self-destruction with age. The easiest to target are molecules that circulate in the blood. Last week, I covered a few that decrease in blood concentration as we age, and that cripple our defenses. This week, I’ll talk about signals that increase as we age, and that activate self-destruction. There are two principal mechanisms of active self-destruction: inflammation and apoptosis=cell suicide. Both mechanisms are important to the healthy functioning of the body. Inflammation is our first defense against invading pathogens. Apoptosis elimnates diseased and cancerous cells before they can become a problem. But in old age, both are co-opted for self-destruction. Healthy tissues in the body are destroyed by apoptosis, and inflammation leads to arterial damage and heart disease, DNA damage and cancer.
The blood signals, too, are have helpful roles earlier in life, but turn traitorous with age.
Bioengineers, Todd Coleman of the University of California, San Diego, and José del R. Millán of the Swiss Federal Institute of Technology in Lausanne, Switzerland, discuss the latest in neurotechnology and what’s next for this field.