h+ Magazine

Until the mid-1990s, the term "nanotechnology" referred to the goal of creating vast arrays of nanoscale assemblers to fabricate useful human-scale products from scratch in an entirely automated process and with atomic precision. Since then, the word has come to mean anything from stain-resistant pants to branches of conventional chemistry — generally anything involving nanoscale objects. But the dream of a new Industrial Revolution based on nanoscale manufacturing has not died, as demonstrated most vividly by the work of NYU professor of chemistry Dr. Nadrian Seeman.

In a 2009 article in Nature Nanotechnology, Dr. Seeman shared the results of experiments performed by his lab, along with collaborators at Nanjing University in China, in which scientists built a two-armed nanorobotic device with the ability to place specific atoms and molecules where scientists want them. The device was approximately 150 x 50 x 8 nanometers in size — over a million could fit in a single red blood cell. Using robust error-correction mechanisms, the device can place DNA molecules with 100% accuracy. Earlier trials had yielded only 60-80% accuracy.

The nanorobotic arm is built out of DNA origami: large strands of DNA gently encouraged to fold in precise ways by interaction with a few hundred short DNA strands. The products, around 100 nanometers in diameter, are eight times larger and three times more complex than what could be built with a simple crystalline DNA array, vastly expanding the space of possible structures. Other nanoscale structures or machines built by Dr. Seeman and his collaborators including a nanoscale walking biped, truncated DNA octahedrons, and sequence-dependent molecular switch arrays. Dr. Seeman has exploited structural features of DNA thought to be used in genetic recombination to operate his nanoscale devices, tapping into the very processes underlying all life.

The advances in DNA nanotechnology keep coming, and many observers are wondering if this will be the path that leads us to the next Industrial Revolution. Only time — and many more experiments — will tell.