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Johns Hopkins Conducts Clinical Trials Applying Deep Brain Stimulation to Alzheimer’s Patients

 

Researchers at Johns Hopkins Medicine are testing the first “brain pacemaker”, a device which provides for deep brain stimulation, for Alzheimer’s patients.

According to Wikipedia, deep brain stimulation a form of neural prosthetic which is already used for “treatment-resistant movement and affective disorders such as chronic painParkinson’s diseasetremor and dystonia.[1] ” However, despite the “long history of DBS” the underlying principles and mechanisms of its operation remain unclear. However, importantly, since DBS directly changes brain activity in a controlled manner (it can be adjusted and turned on and off) it is one of only a few neurosurgical enhancement methods that allows for blinded studies.

Of particular interest to Transhumanists are two papers. In 2007, Nature reported that scientists in the US had stimulated a man who had been in a minimally conscious state for six years using DBS.

The second paper, Stimulating personality: Ethical criteria for deep brain stimulation in psychiatric patients and for enhancement purposes,  discusses the use of DBS as a personal enhancement both to improve memory and to gain control over mood or hedonic set point.

“The findings that DBS can alleviate anhedonia [16] or enhance memory function [22] plus the experience that patients can selectively choose stimula- tion parameters depending on how they want to feel, e.g., calm for every day or more “revved up” for a party [62], open up a completely new application of DBS in the future. It could possibly be used not only for ameliorating psychiatric disease states, but also for enhancing mood and cognition in healthy subjects.”

See http://onlinelibrary.wiley.com/doi/10.1002/biot.200800187/abstract

The implantation technique is invasive requiring neurosurgery, and DIY DBS is therefore not likely something garage biohackers are going to be undertaking any time soon.

The Press Release follows:

Researchers at Johns Hopkins Medicine in November surgically implanted a pacemaker-like device into the brain of a patient in the early stages of Alzheimer’s disease, one of the first such operations in the United States. The device, which provides deep brain stimulation and has been used in thousands of people with Parkinson’s disease, is seen as a possible means of boosting memory and reversing cognitive decline.

The surgery is part of a federally funded, multicenter clinical trial marking a new direction in clinical research designed to slow or halt the ravages of the disease, which slowly robs its mostly elderly victims of a lifetime of memories and the ability to perform the simplest of daily tasks, researchers at Johns Hopkins say. Instead of focusing on drug treatments, many of which have failed in recent clinical trials, the research focuses on the use of the low-voltage electrical charges delivered directly to the brain. There is no cure for Alzheimer’s disease.

As part of a preliminary safety study in 2010, the devices were implanted in six Alzheimer’s disease patients in Canada. Researchers found that patients with mild forms of the disorder showed sustained increases in glucose metabolism, an indicator of neuronal activity, over a 13-month period. Most Alzheimer’s disease patients show decreases in glucose metabolism over the same period.

The first patient in the new trial underwent surgery at The Johns Hopkins Hospital, and a second patient is scheduled for the same procedure in December. The surgeries at Johns Hopkins are being performed by neurosurgeon William S. Anderson, M.D.

“Recent failures in Alzheimer’s disease trials using drugs such as those designed to reduce the buildup of beta amyloid plaques in the brain have sharpened the need for alternative strategies,” says Paul B. Rosenberg, M.D., an associate professor of psychiatry and behavioral sciences at the Johns Hopkins University School of Medicine, and site director of the trial’s Johns Hopkins location. “This is a very different approach, whereby we are trying to enhance the function of the brain mechanically. It’s a whole new avenue for potential treatment for a disease becoming all the more common with the aging of the population.”

Some 40 patients are expected to receive the deep brain stimulation implant over the next year or so at Johns Hopkins and four other institutions in North America as part of the ADvance Study led by Constantine G. Lyketsos, M.D., M.H.S., a professor of psychiatry and behavioral sciences at the Johns Hopkins University School of Medicine, and Andres Lozano, M.D., Ph.D., chairman of the neurology department at the University of Toronto. Only patients whose cognitive impairment is mild enough that they can decide on their own to participate will be included in the trial.

Other sites performing the operation, supported by the National Institutes of Health’s National Institute on Aging (R01AG042165), are the University of Toronto, the University of Pennsylvania, the University of Florida, and Banner Health System in Phoenix, Ariz. The medical device company, Functional Neuromodulation Ltd., is also supporting the trial.

“We are very excited about the possibilities of this potentially new way to treat Alzheimer’s,” says Lyketsos, director of the Johns Hopkins Memory and Alzheimer’s Treatment Center in Baltimore.

While experimental for Alzheimer’s patients, more than 80,000 people with the neurodegenerative disorder Parkinson’s disease have undergone the procedure over the past 15 years, with many reporting fewer tremors and requiring lower doses of medication afterward, Lyketsos says. Other researchers are testing deep brain stimulation to control depression and obsessive-compulsive disorder resistant to other therapies.

The surgery involves drilling holes into the skull to implant wires into the fornix on either side of the brain. The fornix is a brain pathway instrumental in bringing information to the hippocampus, the portion of the brain where learning begins and memories are made, and where the earliest symptoms of Alzheimer’s appear to arise. The wires are attached to a pacemaker-like device, the “stimulator,” which generates tiny electrical impulses into the brain 130 times a second. The patients don’t feel the current, Rosenberg says.

For the trial, all of the patients will be implanted with the devices. Half will have their stimulators turned on two weeks after surgery, while the other half will have their stimulators turned on after one year. Neither the patients nor the doctors treating them will know which group gets an early or later start.

“Deep brain stimulation might prove to be a useful mechanism for treating Alzheimer’s disease, or it might help us develop less invasive treatments based on the same mechanism,” Rosenberg says.

By 2050, the number of people age 65 and older with Alzheimer’s disease may triple, experts say, from 5.2 million to a projected 11 million to 16 million, unless effective treatments are found.

For more information:

http://www.hopkinsmedicine.org/psychiatry/specialty_areas/memory_center/research.html

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