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Comprehensive genetic study paves way for new blood-pressure medicines

Blood pressureEight previously unknown genes that affect blood pressure were recently identified in a comprehensive international study comprising 34,433 Europeans. The findings of the study, in which Uppsala University researchers participated, are being presented today in the Web edition of Nature Genetics.

High blood pressure is a major contributing cause of cardiovascular disorders. Previous studies have shown that it is extremely difficult to identify genes that affect blood pressure, partly because blood pressure is impacted by non-genetic factors, such as exercise and intake of salt in food, and partly because there are many genes that work together to affect blood pressure.

In the present study, a concerted effort was made by 93 research teams in 14 countries to find genes that affect blood-pressure levels in healthy individuals. To identify these genes, blood-pressure levels were monitored in those participating in the study, and DNA samples were gathered. The entire human genome was mapped systematically by analyzing the DNA samples with the help of hundreds of thousands of genetic markers, so-called SNP markers. Sweden was represented in the study by three research teams: Ann-Christine Syvänen’s research group and the SNP technology platform at Uppsala University, a group from the Karolinska Institute, and a group from Lund University. The study included DNA samples from 2,000 Swedes.

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